Runs single variant and aggregate test for genetic data. Implements Single-variant, Burden, SKAT, SKAT-O and SMMAT tests for Continuous or Dichotomous outcomes. All tests account for familiar relatedness through kinship matrixes. Underlying functions adapted from: Conomos MP and Thornton T (2016). GENESIS: GENetic EStimation and Inference in Structured samples (GENESIS): Statistical methods for analyzing genetic data from samples with population structure and/or relatedness. R package version 2.
This is a companion discussion topic for the original entry at github.com/AnalysisCommons/genesis_wdl/genesis_tests