github.com/kbolton-lab/ArCH/ArCCH

BoltonLab (Ar)tifact Filtering (C)lonal (H)ematapoiesis Variant Calling Pipeline

This pipeline is designed to process mutant/wildtype H.sapiens sequencing data from Illumina based sequencing for low VAF CH variants. It features four variant callers (Mutect2, VarDictJava, Lofreq2, and Pindel) for variant detection and performs various false positive filters and detection methods (fp_filter, PoN Fisher’s Exact Test, XGB model, etc.). This pipeline also generates VEP style annotations for all ca


This is a companion discussion topic for the original entry at github.com/kbolton-lab/ArCH/ArCCH