Aggregate Association Testing workflow runs aggregate association tests, using Burden, SKAT [1], fastSKAT [2], SMMAT [3], or SKAT-O [4] to aggregate a user-defined set of variants. Association tests are parallelized by segments within chromosomes.

Define segments splits the genome into segments and assigns each aggregate unit to a segment based on the position of its first variant. Note that number of segments refers to the whole genome, not a number of segments per chromosome. Association

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