This workflow creates a null model from phenotype data with the GENESIS biostatistical package. This null model can then be used for association testing. This workflow also runs single variant and aggregate test for genetic data. Implements Single-variant, Burden, SKAT, SKAT-O and SMMAT tests for Continuous or Dichotomous outcomes. All tests account for familiar relatedness through kinship matrixes. Underlying functions adapted from: Conomos MP and Thornton T (2016). GENESIS: GENetic EStimation
This is a companion discussion topic for the original entry at github.com/AnalysisCommons/genesis_wdl/genesis_GWAS