TWAS Pipeline
This repository contains R scripts and WDL workflows for running transcriptome-wide association studies (TWAS) from SuSiE fine-mapping results and GWAS summary statistics.
The main analysis combines fine-mapped molecular QTL weights with GWAS Z-scores to test whether genetically predicted molecular trait levels are associated with a GWAS trait. The repository also includes a conditional rare-variant TWAS follow-up that separates each gene model into common and rare components a
This is a companion discussion topic for the original entry at github.com/AoU-Multiomics-Analysis/TWAS/ManifestTWAS