Until now, most Deep Mutational Scanning (DMS) experiments relied on variant-specific barcoded libraries for sequencing. This method enabled DMS on large proteins and led to many great publications. Recently, efforts have increased to make use of the classic and more simple random fragmentation-based short-read sequencing (“shotgun-sequencing”). This saves time and money and due to its simpler experimental design is less prone to mistakes. dmscore handles the essential computational steps, proce
This is a companion discussion topic for the original entry at github.com/nf-core/deepmutscan